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The goal of our research is to understand the mechanisms that govern cell fate decisions in epithelial stem cell lineages.

 

whole ovariole 001 stylizedResearch Interests

Our laboratory uses the Drosophila ovary as a model for studying the fundamental properties of epithelial stem cells, their associated niche, and the connection between epithelial stem cells and cancer. We are interested in questions such as:

  • How is stem cell fate maintained within a dynamic epithelial tissue?
  • What is the nature of the epithelial stem cell niche?
  • What is the genetic basis of competition for the stem cell niche?
  • Do stem cell defects contribute to cancer and other pathologies?

 

Stem cells in the Drosophila ovarian epithelium

The follicular epithelium in the Drosophila ovary is an ideal model for the study of epithelial biology. It possesses many classical epithelial features, such as a columnar cell shape, apical/basal polarity, and canonical cell adhesion complexes, and yet is a relatively simple tissue and is highly tractable for molecular and cell biological analysis. Combined with the powerful genetic tools available in Drosophila, this allows us to address questions in epithelial stem cell and tissue biology with single-cell resolution in the natural, in vivo context.